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  Timothy Bryan, CEO of healthcare software developer GalaxE.Solutions, opened an office downtown three years ago. His firm employs 150 people here and plans to expand to 500 within the next two years in what he described as a "cost-effective" city where the rent is low and nearby universities, such as Detroit's Wayne State University and the University of Michigan in Ann Arbor, churn out well-educated graduates willing to work for much less because of the low cost of living. Local IT firms say they tend to pay software engineers as little as half the going rate in California's Silicon Valley.