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 http://www.bilaffarenab.com/?effexor-450-mg-daily.pdf#night effexor 300 mg weight loss  MCK and its peers - both in the U.S. and in Europe - continue to benefit from the unprecedented wave of branded drug patent expirations in calendar 2011-2014. Most drug channel participants, including distributors, earn higher margins - though less revenues - on the sale of lower-cost generic drugs. Fitch believes much of the margin expansion MCK and its peers have achieved in recent years is durable, as generic penetration in the U.S. is likely to remain at or above 80%.As the pace of branded-to-generic conversion slows post-2015, Fitch expects top-line and margin growth to benefit from biosimilars, as well as new branded biologic drugs. Pharmaceutical wholesalers generally earn higher margins on more expensive biologics, compared to traditional drugs, and Fitch thinks biosimilars potentially represent an even more compelling margin expansion opportunity for drug distributors in the intermediate-to-longer term.